J Ruth Wu-Wong Selected Research

Calcitriol Receptors (Calcitriol Receptor)

12/2020	A Novel Vitamin D Receptor Agonist, VS-105, Improves Bone Mineral Density without Affecting Serum Calcium in a Postmenopausal Osteoporosis Rat Model.
1/2017	Vitamin D receptor agonist VS-105 directly modulates parathyroid hormone expression in human parathyroid cells and in 5/6 nephrectomized rats.
2/2015	Vitamin D receptor agonist VS-105 improves cardiac function in the presence of enalapril in 5/6 nephrectomized rats.
1/2013	Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats.
9/2011	VS-105: a novel vitamin D receptor modulator with cardiovascular protective effects.
6/2011	Differential effects of vitamin d receptor agonists on gene expression in neonatal rat cardiomyocytes.
1/2010	Vitamin d receptor activation mitigates the impact of uremia on endothelial function in the 5/6 nephrectomized rats.
9/2009	Are vitamin D receptor activators useful for the treatment of thrombosis?
9/2008	Endothelial dysfunction and chronic kidney disease: treatment options.
11/2007	Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells.

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J Ruth Wu-Wong Research Topics

Disease

19	Chronic Renal Insufficiency 01/2017 - 03/2004
9	Secondary Hyperparathyroidism 01/2017 - 03/2005
5	Uremia 04/2015 - 10/2007
5	Neoplasms (Cancer) 11/2007 - 08/2002
4	Vascular Calcification 01/2017 - 07/2006
3	Osteoporosis 12/2020 - 03/2004
3	Hypercalcemia (Milk Alkali Syndrome) 01/2017 - 01/2007
3	Hypertension (High Blood Pressure) 02/2015 - 10/2007
3	Fibrosis (Cirrhosis) 02/2015 - 01/2013
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 02/2015 - 09/2011
3	Cardiovascular Diseases (Cardiovascular Disease) 09/2008 - 03/2005
3	Chronic Kidney Failure (Chronic Renal Failure) 03/2007 - 03/2004
2	Bone Resorption 12/2020 - 01/2006
2	Hyperphosphatemia 01/2010 - 07/2006
2	Thrombosis (Thrombus) 09/2009 - 01/2007
2	Psoriasis (Pustulosis Palmaris et Plantaris) 09/2009 - 03/2004
2	Disease Progression 09/2008 - 08/2002
2	Breast Neoplasms (Breast Cancer) 01/2006 - 09/2003
1	Postmenopausal Osteoporosis 12/2020
1	Heart Failure 01/2011
1	Cardiomegaly (Heart Hypertrophy) 01/2011
1	Atherosclerosis 01/2011
1	Vitamin D Deficiency 01/2011
1	Leukemia 04/2006
1	Osteomalacia 03/2006
1	Hypocalcemia 03/2006
1	Colonic Neoplasms (Colon Cancer) 01/2006
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2006
1	Bone Diseases (Bone Disease) 03/2005
1	Neoplasm Metastasis (Metastasis) 09/2003
1	Prostatic Neoplasms (Prostate Cancer) 08/2002
1	Growth Disorders 08/2002
1	Ischemic Stroke 07/2002

Drug/Important Bio-Agent (IBA)

16	Calcitriol Receptors (Calcitriol Receptor)IBA 12/2020 - 01/2006
11	paricalcitol (Zemplar)FDA Link 04/2015 - 03/2004
10	Vitamin D FDA LinkGeneric 04/2015 - 03/2004
9	Calcitriol (Calcijex)FDA LinkGeneric 12/2020 - 03/2004
8	CalciumIBA 12/2020 - 03/2004
7	Parathyroid Hormone (Parathormone)IBA 02/2015 - 03/2004
5	Phosphates (Orthophosphate)IBA 01/2016 - 03/2004
4	Phosphorus (Red Phosphorus)IBA 08/2013 - 03/2006
3	5- (2- (1- (1- (3- hydroxy- 2,3- dimethylbutoxy)ethyl)- 7alpha- methyldihydro- 1H- inden- 4(2H,5H,6H,7H,7alphaH)- ylidene)ethylidene)- 2- methylenecyclohexane- 1,3- diolIBA 12/2020 - 09/2011
2	Messenger RNA (mRNA)IBA 08/2013 - 01/2006
2	Pharmaceutical PreparationsIBA 01/2013 - 07/2002
2	1 alpha-hydroxyergocalciferol (doxercalciferol)FDA Link 09/2011 - 01/2010
2	Hormones (Hormone)IBA 06/2011 - 08/2002
2	hydroxide ionIBA 01/2011 - 07/2006
2	Plasminogen Activators (Plasminogen Activator)IBA 01/2007 - 01/2006
2	ReninIBA 01/2007 - 03/2006
2	Endothelins (Endothelin)IBA 08/2002 - 07/2002
1	DNA (Deoxyribonucleic Acid)IBA 04/2015
1	alfacalcidolIBA 04/2015
1	Enalapril FDA LinkGeneric 02/2015
1	Sevelamer (RenaGel)FDA Link 06/2014
1	SodiumIBA 06/2014
1	Brain Natriuretic Peptide (Natrecor)FDA Link 08/2013
1	Cinacalcet (Sensipar)FDA Link 08/2013
1	6- (2- (1- (1- (3- ethyl- 3- hydroxypentyloxy)ethyl)- 7- methyldihydro- 1H- inden- 4(2H,5H,6H,7H,7alphaH)- ylidene)ethylidene)spiro(2.5)octane- 4,8- diolIBA 01/2013
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2010
1	salicylhydroxamic acid (SHAM)IBA 01/2010
1	LipidsIBA 09/2008
1	ThiazolidinedionesIBA 09/2008
1	Hypoglycemic Agents (Hypoglycemics)IBA 09/2008
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2008
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2007
1	Tumor Viral Antigens (Large T Antigen)IBA 11/2007
1	PPAR gammaIBA 11/2007
1	Calcium-Sensing ReceptorsIBA 10/2007
1	ThrombomodulinIBA 01/2007
1	Plasminogen Activator Inhibitor 1IBA 01/2007
1	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)IBA 03/2006
1	Atrial Natriuretic Factor (ANF)IBA 03/2006
1	Vitamin D3 24-HydroxylaseIBA 01/2006
1	1,25-dihydroxyvitamin DIBA 01/2006
1	EnzymesIBA 01/2006
1	Endothelin A ReceptorIBA 09/2003
1	Endothelin-1 (Endothelin 1)IBA 09/2003
1	AtrasentanIBA 08/2002
1	Endothelin Receptor AntagonistsIBA 08/2002
1	S 0139 (97-139)IBA 07/2002

Therapy/Procedure

5	Therapeutics 01/2017 - 08/2002
1	Nephrectomy 10/2007
1	Renal Dialysis (Hemodialysis) 03/2004
1	Castration 08/2002